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  • Title: Effectiveness of topically applied halofuginone in management of subglottic stenosis in rats.
    Author: Ertuğrul EE, Cekin IE, Cincik H, Doğru S, Güngör A.
    Journal: Otolaryngol Head Neck Surg; 2009 May; 140(5):720-3. PubMed ID: 19393418.
    Abstract:
    OBJECTIVE: The aim of the study is to ascertain the antifibrotic effect of topically applied halofuginone after acute subglottic injury. MATERIALS AND METHODS: After standardized trauma to subglottic area, rats were divided into two groups: the study group that received treatment and the control group that did not. The subjects were treated with topical application of cottonoid soaked in 30 mg/dL halofuginone solution for 5 minutes after subglottic trauma. The larynx specimens were examined histopathologically by light microscopy to assess fibrosis, epithelialization, inflammation, and necrosis. RESULTS: The fibrosis indexes of the treated group were significantly less than those of the control group (P < 0.05). CONCLUSIONS: Topically applied halofuginone hydrobromide decreases fibrosis/scar tissue formation secondary to experimentally induced acute subglottic trauma.
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