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  • Title: Novel carbazole and acyl-indole antimitotics.
    Author: Barta TE, Barabasz AF, Foley BE, Geng L, Hall SE, Hanson GJ, Jenks M, Ma W, Rice JW, Veal J.
    Journal: Bioorg Med Chem Lett; 2009 Jun 01; 19(11):3078-80. PubMed ID: 19394222.
    Abstract:
    In the course of our Heat Shock 90 program, certain carbazole compounds were identified which had an off-target antiproliferative activity. To understand the off-target activity, we studied one analog with strong activity. We discovered that it had an effect on tubulin polymerization kinetics and was competitive with colchicine. Additional analogs were made, and a number of potent compounds were identified.
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