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  • Title: Random decarboxylation of uroporphyrinogen III by human hepatic uroporphyrinogen decarboxylase.
    Author: Luo JL, Lim CK.
    Journal: J Chromatogr; 1991 May 31; 566(2):409-13. PubMed ID: 1939452.
    Abstract:
    The type III heptacarboxylic porphyrinogens derived from enzymic decarboxylation of an acetic acid substituent on uroporphyrinogen III to a methyl group by human hepatic uroporphyrinogen decarboxylase has been analysed by reversed-phase high-performance liquid chromatography with electrochemical detection. The results showed that all four possible heptacarboxylic acid porphyrinogen isomers, with the methyl group attached to rings A, B, C and D of the tetrapyrrole macrocycle, respectively, were formed in almost equal proportions. It was concluded that the normal pathway of uroporphyrinogen III decarboxylation in human liver follows a random mechanism.
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