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  • Title: Sensitive one-step extraction procedure for column liquid chromatographic determination of fluvoxamine in human and rat plasma.
    Author: Van der Meersch-Mougeot V, Diquet B.
    Journal: J Chromatogr; 1991 Jul 05; 567(2):441-9. PubMed ID: 1939476.
    Abstract:
    A normal-phase column liquid chromatographic assay for fluvoxamine, a recently introduced atypical antidepressant, has been developed. Prior to analysis, aliquots of alkalinized plasma were extracted with n-hexane. These extracts were then injected into a 5-microns Resolve spherical silica column. Fluvoxamine and the internal standard, clovoxamine, were detected at a wavelength of 254 nm. Standard curves were linear over the concentration range 2-400 ng/ml. Acceptable coefficients of variation were obtained for both within-run and day-to-day studies. The estimated limit of detection is 0.5 ng/ml, and selected drugs checked for coadministration show no analytical interference. This assay was used to evaluate the pharmacokinetics of fluvoxamine in rats.
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