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  • Title: Development of a 1-step cell-based assay for cost-effective screening of antiviral drugs for vaccinia virus.
    Author: Jesus DM, Santos ES, Schnellrath LC, Damaso CR.
    Journal: Diagn Microbiol Infect Dis; 2009 Jul; 64(3):350-3. PubMed ID: 19395220.
    Abstract:
    We report a 1-step assay to screen antiviral substances combining the simultaneous application of cells, virus sample, and drug to 96-well plates. The results were obtained within 26 h when vaccinia virus plaques were counted or virus-induced cytopathic effect was measured. This fast cost-effective procedure may be used for other cytopathic viruses and is suitable to 1st screening tests.
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