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  • Title: Lichen sclerosus of the oral mucosa: clinicopathological features of six cases.
    Author: Azevedo RS, Romañach MJ, de Almeida OP, Mosqueda-Taylor A, Vega-Memije ME, Carlos-Bregni R, Contreras-Vidaurre E, López-Jornet P, Saura-Inglés A, Jorge J.
    Journal: Int J Oral Maxillofac Surg; 2009 Aug; 38(8):855-60. PubMed ID: 19395238.
    Abstract:
    Lichen sclerosus is a chronic inflammatory mucocutaneous disease, rarely involving the mouth. There are only 20 well-documented cases of oral lichen sclerosus reported in the English-language literature. This report describes the clinicopathological features of 6 cases of oral lichen sclerosus; 5 in women. There were 12 lesions, mainly on the lips (50%) and buccal mucosa (25%). The affected areas appeared as irregular whitish patches, harder than the surrounding tissue. Half of the patients were symptomatic and presented with no associated skin and/or genital lesions. All cases were biopsied, and histopathological features were evaluated using hematoxylin-eosin and Verhoeff's stains, S-100 immunohistochemical reaction and transmission electron microscopy. Management of the oral lesions consisted of surgical excision, intralesional triamcinolone acetonide, oral colchicine, and regular follow-up. There is no effective curative treatment, but there are some options for patient management; and colchicine may be considered an additional choice.
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