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  • Title: Antiplasmodial and antitrypanosomal activity of bicyclic amides and esters of dialkylamino acids.
    Author: Faist J, Seebacher W, Schlapper C, Kaiser M, Brun R, Saf R, Weis R.
    Journal: Bioorg Med Chem; 2009 May 15; 17(10):3595-603. PubMed ID: 19395265.
    Abstract:
    Several bicyclic amides and esters of dialkylamino acids were prepared. Their activities against a multiresistant strain of Plasmodium falciparum and against Trypanosoma brucei rhodesiense (STIB 900) were examined. Structure-activity relationships were discussed. Particularly the ester compounds showed good antiplasmodial and antitrypanosomal activity and a single compound was tested in vivo against Plasmodium berghei.
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