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  • Title: [Virilizing adrenal ganglioneuroma : A rare differential diagnosis in testosterone secreting adrenal tumours].
    Author: Gaisa NT, Klöppel G, Brehmer B, Neulen J, Stephan P, Knüchel R, Donner A.
    Journal: Pathologe; 2009 Sep; 30(5):407-10. PubMed ID: 19396442.
    Abstract:
    Testosterone secreting tumours of the adrenal glands are usually adrenal carcinomas or adenomas. Here we report the rare case of an adrenal ganglioneuroma with ectopic Leydig cells, a so-called virilizing adrenal ganglioneuroma. Clinically it is characterized by symptoms of virilization, histologically by the occurrence of a population of eosinophilic cells. In the absence of crystalloids of Reinke this cell population can be identified as Leydig cells based on positive immunohistochemical staining of inhibin and calretinin.
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