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  • Title: The application of the phosphoramidate ProTide approach confers micromolar potency against hepatitis C virus on inactive agent 4'-azidoinosine: kinase bypass on a dual base/sugar modified nucleoside.
    Author: McGuigan C, Daverio F, Nájera I, Martin JA, Klumpp K, Smith DB.
    Journal: Bioorg Med Chem Lett; 2009 Jun 01; 19(11):3122-4. PubMed ID: 19398331.
    Abstract:
    Novel phosphoramidate ProTides derived from 4'-azidoinosine have been prepared and evaluated in the replicon assay against hepatitis C Virus (HCV). The parent nucleoside analogue is inactive in this assay, while the ProTides are active at low microM levels in some cases. This is a rare example of an inosine nucleoside analogue with potent antiviral activity and further supports the notion of ProTides as a drug discovery motif.
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