These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Interleukin-1 genetic polymorphism: association with gastric cancer in the high-risk Central-Western population of Venezuela].
    Author: Cañas M, Morán Y, Rivero MB, Bohórquez A, Villegas V, Rendón Y, Ramírez E, Valderrama E, Briceño Z, Chiurillo MA.
    Journal: Rev Med Chil; 2009 Jan; 137(1):63-70. PubMed ID: 19399323.
    Abstract:
    BACKGROUND: Genetic predisposition may play a role in the prevalence of gastric cancer (GC). AIM: To investigate the relationship between selected interleukin-1 (IL-1) loci polymorphisms and gastric cancer risk in the Central-Western region of Venezuela, where gastric cancer represents the first cause of cancer-related deaths. MATERIAL AND METHODS: In a case-control study we compared the frequencies of IL-1B-511 and IL-1B+3954 biallelic polymorphism, and the pentallelic VNTR of IL-IRN in 84 gastric adenocarcinoma paraffin-embedded biopsies and 84 endoscopic biopsies from cancer-free controls. RESULTS: No significant increase in genotypic frequencies in gastric cancer was observed for any of the IL-1B-511 allelic combinations. However, in a logistic regression analysis, a significant association emerged for the IL-1B+3954C carrier genotype (odds ratio (OR): 6.2; 95% confidence intervals (CI) 1.3-28.8). On the other hand, a significantly higher risk was evidenced for the IL-IRN*2/*2 genotype (OR: 7.0; 95% CI2.3-21.5). Only patients with a well/moderately-differentiated adenocarcinoma that were homozygotes for the E-IRN*2/*2 genotype, had a higher risk than the complete gastric cancer group (OR: 8.1, 95% CI 2.5-26.8). Some genotype combinations among IL-1B-511, IL-1B+3954 and IL-IRN showed an increased risk for developing gastric cancer and well/moderate differentiated adenocarcinoma, that was dependent of the presence of IL-IRN*2/*2 genotype. CONCLUSIONS: IL-IRN*2/*2 genotype is associated with increased risk of gastric cancer in the Venezuelan population.
    [Abstract] [Full Text] [Related] [New Search]