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  • Title: Mapping the mouse craniofacial mutation first arch (Far) to chromosome 2.
    Author: Juriloff DM, Harris MJ.
    Journal: J Hered; 1991; 82(5):402-5. PubMed ID: 1940283.
    Abstract:
    First arch (Far) is a semidominant mutation that causes severe craniofacial defects in mice. Here we report the results of linkage studies with the chromosome 2 markers nonagouti, pallid, and Ulnaless. Far is loosely linked to nonagouti (24-37 cM), more closely linked to pallid (13-28 cM), and closely linked to Ulnaless (2.3 +/- 1.5 cM). The embryological defect in Far mutants is confined to one segmentally-derived region of the head, the anterior first branchial arch. It may therefore be significant that, in mapping near Ulnaless, Far also maps in the vicinity of the Hox-4 gene cluster.
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