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  • Title: [The effect of hepatitis B virus X protein on the c-met promoter activity in HepG2 cells].
    Author: Xie B, Tang C, Chen P, Gou YB, Xiao J, DU H.
    Journal: Zhonghua Gan Zang Bing Za Zhi; 2009 Apr; 17(4):292-6. PubMed ID: 19403030.
    Abstract:
    OBJECTIVE: To confirm the effect of hepatitis B virus X (HBx) protein on the c-met promoter activity in HepG2 cells. METHOD: The expression of c-met protein was detected by western blot in HBx-transfected HepG2 cells, the human c-met promote activity was checked by luciferase assay using five different constructs with deletion or point mutation. RESULTS: HBx protein stimulated the expression of the c-met in HepG2 cells. The enhanced expression of c-met in HBx-transfected cells was mediated by the activation of AP-2 and SP-1 transcriptional activity at the c-met promoter region (-183bp--100bp), HBx increased the invasiveness of HepG2 cells as determined by Matrigel invasion assay. CONCLUSION: These results suggests that HBx induces the expression of c-met through the activation of AP-2 and SP-1 activity at the promoter region; in addition, our data indicate that HBx stimulates the invasive potential of HepG2 cells.
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