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  • Title: Expression of angiopoietins 1, 2 and their common receptor tie-2 in relation to the size of endothelial lining gaps and expression of VEGF and VEGF receptors in idiopathic menorrhagia.
    Author: Mints M, Blomgren B, Palmblad J.
    Journal: Fertil Steril; 2010 Jul; 94(2):701-7. PubMed ID: 19406397.
    Abstract:
    OBJECTIVE: To investigate whether idiopathic menorrhagia (IM) is associated with alterations of the vascular expression of angiopoietin-1, angiopoietin-2, and tie-2 receptor. DESIGN: Prospective clinical study. SETTING: University Hospital, Department of Gynecology. PATIENT(S): Twenty-four patients with IM and 18 women with eumenorrhea. INTERVENTION(S): Endometrial samples underwent immunohistochemical staining for CD34, angiopoetin-1, angiopoietin-2, tie-2, and smooth muscle actin-alpha. Previously published data on gap size and expression of vascular endothelial growth factor family members were used. MAIN OUTCOME MEASURE(S): Differences in immunostaining for these markers by computer-assisted stereological analysis. RESULT(S): There was significantly more angiopoetin-1 positive vessels in IM in the secretory phase, but not of angiopoetin-2 and tie-2, compared with controls. Densities of angiopoetin-1 positive vessels correlated significantly to those of angiopoetin-2 and vascular endothelial growth factor receptor 3. Smooth muscle actin-alpha positive pericytes covered the gaps. Double staining for CD34 and tie-2 receptor was partly identical, but gaps were covered by tie-2 stain. CONCLUSION(S): The discrete deregulation observed of the angiopoetin-1 expression before menstruation might affect vascular integrity, thereby contributing to the excessive blood loss in IM.
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