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  • Title: Optical detection of NMR J-spectra at zero magnetic field.
    Author: Ledbetter MP, Crawford CW, Pines A, Wemmer DE, Knappe S, Kitching J, Budker D.
    Journal: J Magn Reson; 2009 Jul; 199(1):25-9. PubMed ID: 19406678.
    Abstract:
    Scalar couplings of the form JI(1) x I(2) between nuclei impart valuable information about molecular structure to nuclear magnetic-resonance spectra. Here we demonstrate direct detection of J-spectra due to both heteronuclear and homonuclear J-coupling in a zero-field environment where the Zeeman interaction is completely absent. We show that characteristic functional groups exhibit distinct spectra with straightforward interpretation for chemical identification. Detection is performed with a microfabricated optical atomic magnetometer, providing high sensitivity to samples of microliter volumes. We obtain 0.1 Hz linewidths and measure scalar-coupling parameters with 4-mHz statistical uncertainty. We anticipate that the technique described here will provide a new modality for high-precision "J spectroscopy" using small samples on microchip devices for multiplexed screening, assaying, and sample identification in chemistry and biomedicine.
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