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  • Title: Fluorenone alkaloid from Caulophyllum robustum Maxim. with anti-myocardial ischemia activity.
    Author: Wang S, Wen B, Wang N, Liu J, He L.
    Journal: Arch Pharm Res; 2009 Apr; 32(4):521-6. PubMed ID: 19407969.
    Abstract:
    A new fluorenone alkaloid (caulophine) was isolated from the radix of Caulophyllum robustum Maxim. (collected from the Qinling mountains) using cell membrane chromatography as the screening method. Caulophine was identified as 3-(2-(dimethylamino)ethyl)-4,5-dihydroxy-1,6-dimethoxy-9H-fluoren-9-one based on physicochemic and spectroscopic analyses, particularly by NMR spectroscopic data (i.e., COSY, HMQC, HMBC, NOESY). Caulophine possessed anti-myocardial ischemia activity.
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