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  • Title: Clinical profile and risk factors for keratoplasty and development of hydrops in north Indian patients with keratoconus.
    Author: Sharma R, Titiyal JS, Prakash G, Sharma N, Tandon R, Vajpayee RB.
    Journal: Cornea; 2009 May; 28(4):367-70. PubMed ID: 19411952.
    Abstract:
    PURPOSE: To review the profile of Indian patients with keratoconus and evaluate risk factors for keratoplasty and development of hydrops. METHODS: In this prospective observational study, 120 consecutive patients with bilateral or unilateral keratoconus presenting to the cornea services of a large, tertiary care ophthalmic center were evaluated. A detailed history including information about the age at onset of symptoms, nature of ocular complaints, and so on was taken. Investigations included visual acuity, slit-lamp examination, keratometry, pachymetry, and videokeratography. RESULTS: There were 76 males and 44 females (mean age at presentation was 20.07 +/- 6.4 years). Five percent families revealed a positive family history. Earlier age at onset (P = 0.002) and eye rubbing (P = 0.02) were found significantly associated with increased risk for surgery. Eyes undergoing surgery had steeper corneas, lower best-corrected visual acuity, corneal scarring, and vernal keratoconjunctivitis were significant risk factors (P values: 0.001, 0.0001, and 0.04, respectively). Hydrops represents a significant independent risk factor for surgery (P = 0.0001). Patients with younger age at onset (P value 0.01), history of eye rubbing (P value 0.02), and atopy (P value 0.01) had higher risk for developing corneal hydrops. CONCLUSION: This knowledge of risk factors should enable clinicians and patients to make more informed decisions regarding the management of keratoconus.
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