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  • Title: Stereochemical studies of hexylitaconic acid, an inhibitor of p53-HDM2 interaction.
    Author: Nakahashi A, Miura N, Monde K, Tsukamoto S.
    Journal: Bioorg Med Chem Lett; 2009 Jun 01; 19(11):3027-30. PubMed ID: 19414261.
    Abstract:
    Hexylitaconic acid (1) is an intriguing natural product possessing a chiral carbon, and both its enantiomers have been found in nature. Enantiomeric pure (+)-(1) and (-)-(1) were successfully prepared by racemic synthesis followed by enantiomeric separation in a chiral HPLC system. Their absolute configurations were clarified by the vibrational circular dichroism technique using their methyl esters 2 and lactones 3. Their inhibitory activities against the interaction of p53-HDM2 were also examined.
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