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  • Title: Enantioselective synthesis of beta-iodo Morita-Baylis-Hillman esters by a catalytic asymmetric three-component coupling reaction.
    Author: Senapati BK, Hwang GS, Lee S, Ryu DH.
    Journal: Angew Chem Int Ed Engl; 2009; 48(24):4398-401. PubMed ID: 19415700.
    Abstract:
    A catalytic route toward chiral Morita-Baylis-Hillman esters by asymmetric coupling between alpha,beta-acetylenic esters, aldehydes, and trimethylsilyl iodide has been developed (see scheme). The reaction proceeds with high to excellent enantioselectivities, and the products can be transformed into beta-branched derivatives in a single step and with excellent retention of configuration. TMS = trimethylsilyl.
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