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  • Title: Application of copper(II)-dipyridylphosphine catalyst in the asymmetric hydrosilylation of simple ketones in air.
    Author: Zhang XC, Wu Y, Yu F, Wu FF, Wu J, Chan AS.
    Journal: Chemistry; 2009 Jun 08; 15(24):5888-91. PubMed ID: 19418525.
    Abstract:
    Ask a copper: A copper(II) salt/chiral dipyridylphosphine/PhSiH(3) system (see scheme) acts as a very effective and practical catalyst for the asymmetric reduction of heteroaromatic and other types of ketones in air with good-to-excellent enantioselectivities (up to 94%), giving many chiral alcohols that are intermediates for physiologically active compounds. Remarkable temperature effects were observed for some heteroaromatic ketones.
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