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  • Title: Synthesis of some novel bioactive 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones via efficient cross-Claisen condensation.
    Author: Venkat Ragavan R, Vijayakumar V, Suchetha Kumari N.
    Journal: Eur J Med Chem; 2009 Oct; 44(10):3852-7. PubMed ID: 19423195.
    Abstract:
    alpha-Oxy/thio substituted-beta-keto esters were synthesized through an efficient cross-Claisen condensation of aryl oxy/thio acetic acid ethyl esters with acid chlorides, then it is converted in situ into 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones by the addition of hydrazine or hydrazine derivatives and screened for their antibacterial, antifungal activities.
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