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  • Title: Trimetrexate and folinic acid: a valuable salvage option for Pneumocystis jirovecii pneumonia.
    Author: Short CE, Gilleece YC, Fisher MJ, Churchill DR.
    Journal: AIDS; 2009 Jun 19; 23(10):1287-90. PubMed ID: 19424049.
    Abstract:
    The best management strategy for HIV patients who fail to respond to first-line therapy for Pneumocystis jirovecii pneumonia is currently unclear. We identified all patients who were treated with trimetrexate and folinic acid who failed 7 or more days of cotrimoxazole, clindamycin-primaquine or dapsone-trimethoprim between 1996 and 2006. Trimetrexate was tolerated in 100% of cases with no treatment termination secondary to adverse drug reactions. Despite severe disease, 71% of patients were alive after 12 weeks.
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