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  • Title: [Voltage-dependent effects of lidocaine and its metabolite, monoethylglycine xylidide (MEGX), on maximum rate of rise (Vmax) of action potential upstroke in guinea-pig papillary muscles].
    Author: Hiraoka I, Oshita S, Itoh M, Sakabe T, Ban T.
    Journal: Masui; 1991 Sep; 40(9):1394-9. PubMed ID: 1942514.
    Abstract:
    We studied the effects of lidocaine and MEGX on the sodium current, using Vmax as an indicator, at an extracellular potassium concentration ([K]o) of 10 mmol.l-1, and compared the present results with those obtained at 5.4 mmol.l-1 [K]o in our previous study. At 10 mmol.l-1 [K]o, both lidocaine (10 micrograms.ml-1) and MEGX (10 micrograms.ml-1) significantly decreased the Vmax at the steady-state of 1 Hz, caused a significant rate-dependent decrease in Vmax, and slowed the recovery kinetics of Vmax. These effects of both agents were more prominent than those obtained at 5.4 mmol.l-1 [K]o, suggesting that MEGX as well as lidocaine produce voltage-or [K]o-dependent blocking effects on Vmax.
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