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  • Title: Metabolic syndrome and its components as risk factors for first-ever acute ischemic noncardioembolic stroke.
    Author: Maruyama K, Uchiyama S, Iwata M.
    Journal: J Stroke Cerebrovasc Dis; 2009; 18(3):173-7. PubMed ID: 19426885.
    Abstract:
    BACKGROUND: Metabolic syndrome (MetS) has been studied as a cardiovascular risk factor. We evaluated MetS and its individual components as risk factors for acute ischemic noncardioembolic stroke (AINS). METHODS: The relationships of AINS with MetS and its components were analyzed in 200 patients with first-ever AINS and 200 age-matched control subjects. RESULTS: Patients with AINS had a higher MetS prevalence than control subjects (45.5% v 26.5%, P < .001). On logistic regression analysis, the adjusted odds ratio (OR) for MetS as a risk factor for AINS was 2.39 (95% confidence interval [CI] 1.14-4.98, P = .021). The AINS risk increased as the number of MetS components increased. Hypertension (OR 3.21, 95% CI 1.48-6.94, P = .003) and fasting hyperglycemia (OR 2.73, 95% CI 1.53-4.87, P = .001) were particularly significant risk factors among MetS components for AINS. CONCLUSION: MetS is an independent risk factor for AINS. Stroke risk increased as the number of MetS components increased. Hypertension and hyperglycemia were particularly significant components as risk factors for AINS.
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