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  • Title: Comparison of retinal nerve fiber layer thickness measured by Cirrus HD and Stratus optical coherence tomography.
    Author: Sung KR, Kim DY, Park SB, Kook MS.
    Journal: Ophthalmology; 2009 Jul; 116(7):1264-70, 1270.e1. PubMed ID: 19427696.
    Abstract:
    PURPOSE: To study the relationship between retinal nerve fiber layer (RNFL) thickness measured by time domain (Stratus) and spectral domain (Cirrus HD) optical coherence tomography (OCT). DESIGN: Cross-sectional study. PARTICIPANTS: Sixty healthy participants, 48 glaucoma suspects, and 55 subjects with glaucoma. METHODS: Participants were imaged by a single trained operator using the Stratus OCT (fast RNFL scan mode) and Cirrus HD-OCT (optic disc cube mode) at the same visit. MAIN OUTCOME MEASURES: The RNFL thickness as measured by the Stratus OCT (fast RNFL scan mode) and Cirrus HD-OCT (optic disc cube mode) was compared (paired t test). The relationship between RNFL thickness measurements of the 2 OCTs were evaluated using a Pearson correlation analysis. The presence of abnormal classification, as determined by using an internal normative data base in each machine was compared (chi-square test). The sensitivity and specificity of normative classification of 2 OCT measurements were calculated. RESULTS: Average RNFL thickness as determined by the 2 OCT machines was correlated (r = 0.94; P<0.001), but was significantly different with the 2 machines (Stratus, 98.0 mum, standard deviation [SD] 18.0; Cirrus, 85.6 mum, SD 14.6; P<0.001). The Cirrus HD-OCT classified a significantly higher percentage of eyes as abnormal (Stratus, 12.9%; Cirrus, 23.3%; P<0.001) in average RNFL thickness. Cirrus OCT demonstrated higher sensitivity and specificity (63.6% and 100%) than Stratus OCT (40.0% and 96.7%) in normative classification of average RNFL thickness. CONCLUSIONS: There were significant differences in RNFL thickness and normative classification as determined by Stratus OCT and Cirrus HD-OCT despite an excellent correlation of RNFL thickness measurement. Overall sensitivity and specificity were higher with Cirrus OCT. These findings are particularly relevant when an individual undergoes longitudinal follow-up with different OCTs.
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