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  • Title: Chitosan-graft-beta-cyclodextrin scaffolds with controlled drug release capability for tissue engineering applications.
    Author: Prabaharan M, Jayakumar R.
    Journal: Int J Biol Macromol; 2009 May 01; 44(4):320-5. PubMed ID: 19428461.
    Abstract:
    Biodegradable scaffolds composed of chitosan-g-beta-cyclodextrin (chit-g-beta-CD) were prepared by freeze-drying method as synthetic extracellular matrices to fill the gap during the healing process. Due to the presence of beta-CD, these scaffolds can be used as a matrix for drug loading and controlled release. The morphology, swelling and drug release properties of the scaffolds were found to be dependent on the extent of cross-linking density in the scaffolds. The drug dissolution profile showed that chit-g-beta-CD scaffolds provided a slower release of the entrapped ketoprofen than chitosan scaffold. The MTT assay showed that there is no obvious cytotoxicity of chit-g-beta-CD scaffolds cross-linked with 0.01 M of glutaraldehyde against the fibroblasts (L929) cells. These results suggest that chit-g-beta-CD scaffolds may become a potential biodegradable active filling material with controlled drug release capability, which provide a healthy environment and enhance the surrounding tissue regeneration.
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