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  • Title: Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats.
    Author: Xu J, Wang S, Lin Y, Cao L, Wang R, Chi Z.
    Journal: Neurosci Lett; 2009 Mar 27; 453(1):58-61. PubMed ID: 19429016.
    Abstract:
    Ghrelin, a 28-amino-acid peptide, is mainly secreted by the stomach. Evidence has shown ghrelin to have neuroprotective effects. However, whether ghrelin protects hippocampal neurons against cell death in pilocarpine-induced seizures is unknown. We used Nissl staining to show that ghrelin attenuated the neuronal loss caused by pilocarpine-induced seizures in the hippocampus. Ghrelin exerted the protective action through regulating the phosphatidylinositol-3-kinase and Akt pathway. Moreover, ghrelin treatment reversed the decreased ratio of Bcl-2 to Bax induced by seizures while inhibiting the activated caspase-3. Ghrelin can inhibit hippocampal neuronal damage caused by pilocarpine-induced seizures, which might have therapeutic value in seizures.
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