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  • Title: Association study on the NAPG gene and bipolar disorder in the Chinese Han population.
    Author: Li X, Zhang J, Wang Y, Ji J, Yang F, Wan C, Wang P, Feng G, Lindpaintner K, He L, He G.
    Journal: Neurosci Lett; 2009 Jul 03; 457(3):159-62. PubMed ID: 19429185.
    Abstract:
    BACKGROUND: Bipolar disorder is a mental health problem throughout the world. Chromosome 18p11 has been identified by several studies as a susceptiblilty region for bipolar disorder and NAPG, located on 18p11, has been suggested as being associated with bipolar disorder in European population. METHODS: Our study employed five SNPs (rs2290279, rs495484, rs510110, rs617040 and rs473938) to investigate the role of NAPG in the Chinese Han population based on a sample of 465 controls vs. 499 bipolar patients. RESULTS: Rs617040 was excluded from further analysis because of deviation from Hardy-Weinberg equilibrium. Rs473938 and rs2290279 showed significant association in both allele and genotype frequencies (rs473938: allele p=0.0028 after 100,000 permutations, genotype p=0.0018; rs2290279: allele p=0.0042 after 100,000 permutations, genotype p=0.0028). Several combinations of haplotype were found to be associated with bipolar disorder. Haplotype T-A-T of rs473938-rs2290279-rs495484 was defined by confidence intervals algorithm and had a p value of 0.0038 after 100,000 permutations. CONCLUSIONS: Our study supports NAPG as a candidate for susceptibility to bipolar disorder.
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