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  • Title: [Safety and tolerability in the early phase of slow schedule versus fast schedule treatment with 44 micrograms of interferon beta-1a in patients with multiple sclerosis (PARALEN study)].
    Author: Hernandez-Perez MA, Grupo de Investigadores Del Estudio PARALEN.
    Journal: Rev Neurol; ; 48(10):505-8. PubMed ID: 19434583.
    Abstract:
    INTRODUCTION: Interferon (IFN) beta-1a, 44 micrograms, administered three times a week (tiw), is the recommended dose in 'relapsing' multiple sclerosis. During the clinical practice, physicians initiate treatment either with this complete dose, or with escalating dose. AIM: To determine safety of IFN beta-1a 44 micrograms tiw, comparing a complete dose initiation regimen versus an escalating dose initiation. PATIENTS AND METHODS: A total of 247 multiple sclerosis patients were enrolled in this study from 37 different Spanish centers, who initiated treatment with IFN beta-1a 44 micrograms tiw. Safety and tolerability was compared in patients switching from other previous interferon to a direct complete dose regime of IFN beta-1a 44 micrograms tiw vs. an escalating dose regime in naive multiple sclerosis patients. RESULTS: Adverse events were more frequent when administrating interferon in a 'fast-regime' directly with a complete dose. CONCLUSIONS: An escalating dose with IFN beta-1a 44 micrograms tiw is recommended to initiate treatment in multiple sclerosis patients. In patients previously treated with another interferon beta, a complete dose regime initiation can be also scheduled, without significant differences in the reporting of adverse events.
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