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  • Title: [Alternative ways of stress regulation in cells of Saccharomyces cerevisiae: transcriptional activators Msn2 and Msn4].
    Author: Erkina TI, Lavrova MV, Erkin AM.
    Journal: Tsitologiia; 2009; 51(3):271-8. PubMed ID: 19435282.
    Abstract:
    Cell response to stress at the transcriptional level is characterized by the rapid expression of a large set of genes. In yeast Saccharomyces cerevisiae this gene activation is determined by the action of two types of activators--HSF and partially redundant Msn2 and Msn4. While HSF activation mechanisms are relatively well established during the last decade, the mechanisms of regulation by Msn2/4 started to clarify only recently. Some of the important aspects of Msn2/4 regulation include nuclear-cytoplasmic shuttling and targeted degradation of these factors at gene promoters during transcription activation. These and other mechanisms will be discussed in the current review.
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