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  • Title: An injury model myopathy mimicking dystrophy: implications regarding the function of dystrophin.
    Author: Stauber WT, Fritz VK, Clarkson PM, Riggs JE.
    Journal: Med Hypotheses; 1991 Aug; 35(4):358-62. PubMed ID: 1943889.
    Abstract:
    The pathogenesis of dystrophin deficient myopathies remains unknown. Rat and human muscles subjected to severe injury following repeated eccentric muscle actions demonstrate histopathological alterations which mimic a dystrophic process. Immunofluorescent histochemical examination of these injured muscles demonstrates a separation of proteoglycans of the basal lamina from the muscle plasma membrane, the identical histopathological alteration observed in Duchenne muscular dystrophy. These findings are consistent with the hypothesis that dystrophin is essential for maintenance of the structural integrity of the sarcolemma.
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