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  • Title: Injection of day 2 embryo culture supernatant into the uterine cavity did not improve the pregnancy rate of day 3 embryo transfer in patients who underwent in vitro fertilization-embryo transfer: a randomized clinical trial.
    Author: Zhu W, Li X, Fu Z, Tang Z, Chen X, Zhou Y, Geng Q.
    Journal: Fertil Steril; 2010 May 01; 93(7):2216-21. PubMed ID: 19439284.
    Abstract:
    OBJECTIVE: To evaluate the effectiveness of uterine cavity injection of day 2 embryo culture supernatant before day 3 embryo transfer in patients who are undergoing in vitro fertilization-embryo transfer. DESIGN: Randomized controlled trial. SETTING: A reproductive medical centre. PATIENT(S): A total of 90 infertile women, 45 of them in the study group and 45 in the control group. INTERVENTION(S): Uterine cavity infection of day 2 embryo culture supernatant before day 3 embryo transfer. MAIN OUTCOME MEASURE(S): Embryo implantation rate and pregnancy rate. RESULT(S): The pregnancy versus implantation rates in the study group and control group were 48.9% versus 44.4% and 27.3% versus 22.1%, respectively. Although both pregnancy and implantation rates in the study group were higher than those in the control group, no statistically significant differences were found in these two parameters. CONCLUSION(S): Injection of day 2 embryo culture supernatant into the uterine cavity cannot improve the implantation and pregnancy rates of day 3 embryo transfer.
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