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  • Title: Intraperitoneal vascular endothelial growth factor C level is related to peritoneal dialysis ultrafiltration.
    Author: Yang WS, Tsai TJ, Shih CL, Huang JW, Chuang HF, Chen MH, Fang CC.
    Journal: Blood Purif; 2009; 28(1):69-74. PubMed ID: 19439926.
    Abstract:
    BACKGROUND: Local inflammation and neovascularization have a negative influence on peritoneal dialysis (PD). Patients with higher peritoneal transport have higher interleukin-6 (IL-6) and vascular endothelial growth factor-A (VEGF-A) levels in their dialysate. However, the relationship of other members of the VEGF family, such as VEGF-C, to peritoneal transport or ultrafiltration (UF) is yet to be studied. METHODS: Peritoneal cytokine and growth factor levels were determined during the peritoneal equilibration test (PET). Ultrafiltration, peritoneal clearance and residual renal function were also considered. RESULTS: Forty-two PD patients were enrolled. They had been on PD for at least 1 month and free of peritonitis for at least 1 month prior to the study. Patients with high or high average PET had higher dialysate IL-6 and VEGF-C. Dialysate IL-6 and VEGF-C correlated negatively with PET and UF. CONCLUSIONS: Dialysate VEGF-C is related to higher transport rate and poorer UF. The role of VEGF-C in PD deserves further study.
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