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  • Title: Interstitial cells of Cajal in abdominal sepsis and hypertension-induced ileus in rats.
    Author: Lou Z, Li JS.
    Journal: Eur Surg Res; 2009; 43(1):47-52. PubMed ID: 19439971.
    Abstract:
    PURPOSE: To evaluate injury to the myenteric interstitial cells of Cajal (ICC-MY) and assess the role of ICC-MY in gastrointestinal motility in rat models of abdominal sepsis and intra-abdominal hypertension (IAH). MATERIALS AND METHODS: Sprague-Dawley rats were divided into 4 groups; group 1: sham group; group 2: sepsis induced by cecal puncture and ligation; group 3: IAH created by placing a catheter into the abdominal cavity; group 4: sepsis and IAH induced simultaneously. Small intestinal segments were resected 24 h after surgery. Ileum sections stained with HE were assessed pathologically. The spontaneous mechanical activity was evaluated using the organ bath technique. The alterations in ICC-MY networks by immunohistochemical staining for c-Kit and the ultrastructural changes in ICC-MY by transmission electron microscopy were evaluated. RESULTS: There were significant differences in the frequency and amplitude of the bowel segment contractions between groups 1, 2, 3 and 4. These changes were associated with lesions of ICC-MY networks and ultrastructure. CONCLUSIONS: Abdominal sepsis and IAH resulted in damage to ICC-MY networks, leading to disordered intestinal rhythmicity. The combination of sepsis and IAH causes far more serious injury than either sepsis or IAH alone.
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