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  • Title: Optimal sterilization method for the zirconia/alumina composites used for total hip replacements.
    Author: Nam KW, Yoo JJ, Koo KH, Yoon KS, Kim HJ.
    Journal: J Biomed Mater Res B Appl Biomater; 2009 Aug; 90(2):962-6. PubMed ID: 19441113.
    Abstract:
    Zirconia/alumina composite ceramics have been recently developed for total hip arthroplasty because of their excellent mechanical properties and tribologic characteristics. All such materials used clinically must be easily sterilized, but no report has been issued concerning methods for sterilizing zirconia/alumina composite hip prostheses. Here, we show that 50 kGy of gamma irradiation effectively sterilizes both the surfaces and interiors of these materials. In addition, it was found that the commonly used ethylene oxide and 25-kGy gamma irradiation sterilization methods inadequately sterilize deep inside the femoral head. Moreover, no changes in the chemical or mechanical properties of the composites were noted after exposure to 50-kGy gamma irradiation. We suggest that 50-kGy gamma irradiation is an optimal sterilization method for zirconia/alumina composite total hip replacements.
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