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  • Title: Oligopeptide-modified silicon nanowire arrays as multichannel metal ion sensors.
    Author: Bi X, Agarwal A, Yang KL.
    Journal: Biosens Bioelectron; 2009 Jul 15; 24(11):3248-51. PubMed ID: 19443202.
    Abstract:
    Semiconducting nanowires have the potential to function as highly sensitive and selective sensors for label-free detection of biological and chemical species. In this paper, we describe the preparation and applications of oligopeptide-modified single crystal silicon nanowire (SiNW) arrays as multichannel metal ion sensors. Because these SiNW arrays were fabricated by using a "top-down" process, a very high density of individually addressable SiNW (180 SiNWs grouped into 36 clusters) can be manufactured on a single chip. Furthermore, after two different SiNW clusters are modified with Pb(2+)-selective and Cu(2+)-selective oligopeptide, respectively, concentrations of Pb(2+) and Cu(2+) in aqueous solutions can be detected simultaneously and selectively in two different channels. By using the SiNW arrays, we successfully achieved a detection limit of 1 nM for Pb(2+) and 10 nM for Cu(2+), respectively. These results demonstrate the potential utility of oligopeptide-modified SiNW arrays for highly sensitive and selective chemical and biological sensing applications.
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