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  • Title: [Long-term effect of hormonal contraceptives on the behavior of serum lipids].
    Author: Klinger G, Carol W, Hoppe H, Müller B, Bonow A.
    Journal: Zentralbl Gynakol; 1977; 99(5):271-6. PubMed ID: 194435.
    Abstract:
    In order to check the long-term effects of oral contraceptives used in the GDR on certain serum-lipid-fractions, triglycerides, phospholipids, total and free cholesterol, and beta-lipoproteins were determined in four groups of 15 women each, taking the contraceptive preparations Ovosiston, Nonovlon, Gravistat, and Deposiston. Determinations were carried out before and following 3, 6, 12, and 18 month of drug administration. Statistically significant increases of triglycerides occurred under the combined preparations, of phospholipids under Ovosiston and Deposiston and of the beta-lipoproteins under Ovosiston and Gravistat. Total cholesterol showed a slight decrease under all preparations tested. At present the prognostic significance of these slight alterations of serum-lipid-concentrations cannot be estimated completely. To determine the long-term effects of oral contraceptives used in the Democratic Republic of Germany on certain serum lipid fractions, tryglycerides, phospholipids, total and free cholesterol, and beta-lipoproteins were determined in 4 groups of 15 women each on the contraceptives Ovosiston, Nonovlon, Gravistat, and Deposiston. Determinations were carried out before and after 3, 6, 12, and 18 months of drug treatment. Statistically significant increases of triglycerides occurred under the combined preparations, of phospholipids under Ovosiston and Deposiston, and of the beta-lipoproteins under Ovosiston and Gravistat. Total cholesterol showed a slight decrease under all preparations tested. At present the prognostic significance of these slight alterations of serum-lipid concentrations cannot be completely estimated.
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