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  • Title: Antimycobacterial activity of Exocarpos latifolius is due to exocarpic acid.
    Author: Koch M, Bugni TS, Pond CD, Sondossi M, Dindi M, Piskaut P, Ireland CM, Barrows LR.
    Journal: Planta Med; 2009 Oct; 75(12):1326-30. PubMed ID: 19444772.
    Abstract:
    Lipophilic fractions of stem extracts from Exocarpos latifolius, native to Papua New Guinea, showed significant activity against Mycobacterium tuberculosis H37Ra. Bioactivity-guided fractionation yielded exocarpic acid (E-octadeca-13-ene-9,11-diynoic-acid) as the major active component. Several new exocarpic acid analogs were also shown to be active. Exocarpic acid has previously been reported active against gram-positive, but not gram-negative bacteria. Work presented here demonstrates the selective activity of exocarpic acid against Mycobacterium tuberculosis H37Ra.
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