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  • Title: Piroxicam accelerates development of colitis in T-cell receptor alpha chain-deficient mice.
    Author: Nishiyori A, Nagakura Y, Ichikawa K.
    Journal: Eur J Pharmacol; 2009 Aug 01; 615(1-3):241-5. PubMed ID: 19446544.
    Abstract:
    T-cell receptor alpha chain (TCR.alpha)-deficient mice spontaneously develop colitis that resembles human ulcerative colitis; however, the incidence varies among individuals and takes place lately in the life. We have demonstrated that piroxicam induces colitis in non-colitic TCR.alpha-deficient mice, but not wild-type mice, within 14 days. The histological features and cytokine profiles were similar to those seen in spontaneous colitis in TCR.alpha-deficient mice. Dexamethasone prevented piroxicam-induced colitis concurrent with the suppression of interleukin (IL)-1beta, IL-17, tumor necrosis factor alpha and interferon gamma. This modified model of colitis could be useful for the evaluation of potential therapeutics for ulcerative colitis.
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