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  • Title: Unusual pancytopenia secondary to haemophagocytosis syndrome in rickettsioses.
    Author: Premaratna R, Williams HS, Chandrasena TG, Rajapakse RP, Kularatna SA, de Silva HJ.
    Journal: Trans R Soc Trop Med Hyg; 2009 Sep; 103(9):961-3. PubMed ID: 19446860.
    Abstract:
    We report two patients who presented with a long-lasting febrile illness associated with pancytopenia. Both of them had evidence of hypercellular marrow with haemophagocytosis. They were confirmed as having rickettsial infections by serology and had a rapid haematological recovery with anti-rickettsial antibiotics. We highlight the importance of considering rickettsial infections in patients with such clinical presentations, especially in areas where these infections are endemic or re-emerging. Empirical use of anti-rickettsial antibiotics in such situations could be beneficial, when facilities to diagnose rickettsial diseases are not readily available.
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