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  • Title: Myasthenia gravis: measurement of anti-AChR autoantibodies using cell line TE671.
    Author: Voltz R, Hohlfeld R, Fateh-Moghadam A, Witt TN, Wick M, Reimers C, Siegele B, Wekerle H.
    Journal: Neurology; 1991 Nov; 41(11):1836-8. PubMed ID: 1944918.
    Abstract:
    Anti-acetylcholine receptor (AChR) antibodies in myasthenia gravis (MG) can be quantitated using AChR extracted from the human rhabdomyosarcoma cell line TE671 (AChRTE671) as a practical alternative to AChR from human amputated limbs (AChRAMP). We compared the two antigen preparations using serum samples from different clinical groups of MG patients (n = 112) and various controls (n = 189). With two exceptions, both tests were positive or negative in the same patients. However, in the generalized MG group, the TE671 assay yielded significantly lower titers than the AChRAMP assay.
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