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  • Title: Biphasic regulation of proopiomelanocortin messenger RNA concentrations by corticotropin-releasing factor in primary cultures of rat hypothalamic neurons.
    Author: L'Héreault S, Barden N.
    Journal: Neurosci Lett; 1991 Jul 22; 128(2):207-10. PubMed ID: 1945039.
    Abstract:
    Primary cultures of rat hypothalamic neurons in which a 1.1-kb proopiomelanocortin (POMC) mRNA can be detected, were incubated with corticotropin-releasing factor (CRF) for periods of up to 84 h. A cyclic modulation of POMC mRNA concentrations by CRF was noted. A rapid acute inhibition of POMC mRNA levels after 1 h of exposure was followed by a transient stimulation and then by a more prolonged inhibition which reached a nadir after 48 h.
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