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  • Title: Use of radiotherapy to treat life-threatening Kasabach-Merritt syndrome.
    Author: Leong E, Bydder S.
    Journal: J Med Imaging Radiat Oncol; 2009 Feb; 53(1):87-91. PubMed ID: 19453533.
    Abstract:
    Kasabach-Merritt syndrome involves thrombocytopenia, which is usually severe, in association with haemangiomata. We describe two newborn infants who developed life-threatening Kasabach-Merritt syndrome but who were successfully treated. Both had failed to respond adequately to corticosteroids and alpha-interferon. They subsequently received emergency radiotherapy. Both patients had an improvement in their platelet counts. The first infant's haemangioma gradually faded during the first 3 years of life, whereas the second infant's haemangioma had resolved 2 months after radiotherapy. No significant late effects of the radiotherapy have been noted at the 8 and 5 years follow up respectively. Radiotherapy remains an important treatment method in Kasabach-Merritt syndrome when patients fail to respond to other treatments.
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