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  • Title: Oral vaccination of mice against Helicobacter pylori with recombinant Lactococcus lactis expressing urease subunit B.
    Author: Gu Q, Song D, Zhu M.
    Journal: FEMS Immunol Med Microbiol; 2009 Aug; 56(3):197-203. PubMed ID: 19453750.
    Abstract:
    To determine whether a protective immune response could be elicited by oral delivery of a recombinant live bacterial vaccine, Helicobacter pylori urease subunit B (UreB) was expressed for extracellular expression in food-grade bacterium Lactococcus lactis. The UreB-producing strains were then administered orally to mice, and the immune response to UreB was examined. Orally vaccinated mice produced a significant UreB-specific serum immunoglobulin G (IgG) response. Specific anti-UreB IgA responses could be detected in the feces of mice immunized with the secreting lactococcal strain. Mice vaccinated orally were significantly protected against gastric Helicobacter infection following a challenge with H. pylori strain SS1. In conclusion, mucosal vaccination with L. lactis expressing UreB produced serum IgG and UreB-specific fecal IgA, and prevented gastric infection with H. pylori.
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