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  • Title: Brønsted base-modulated regioselective pd-catalyzed intramolecular aerobic oxidative amination of alkenes: formation of seven-membered amides and evidence for allylic C-H activation.
    Author: Wu L, Qiu S, Liu G.
    Journal: Org Lett; 2009 Jun 18; 11(12):2707-10. PubMed ID: 19456146.
    Abstract:
    A novel palladium-catalyzed intramolecular aerobic oxidative allylic C-H amination of olefins has been developed. Brønsted base can modulate the regioselectivity, favoring the formation of 7-membered rings. Mechanistic studies using deuterium-labeled substrates as probes support a rate-determining allylic C-H activation/irreversible reductive elimination pathway.
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