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  • Title: Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions.
    Author: Schuring RP, Hamann L, Faber WR, Pahan D, Richardus JH, Schumann RR, Oskam L.
    Journal: J Infect Dis; 2009 Jun 15; 199(12):1816-9. PubMed ID: 19456232.
    Abstract:
    We investigated the association between a polymorphism of a key innate immunity receptor, Toll-like receptor 1 (TLR1) N248S, and susceptibility to leprosy and its clinical presentation. TLR1 N248S has been shown elsewhere to diminish TLR1 signaling and subsequent leprosy disease. The homozygous genotype SS was more frequent (P=.012) and the heterozygous SN genotype was less frequent (P=.015) in patients with leprosy than in control subjects. Additional observed differences in allelic frequency in patients who experienced reversal reactions and/or erythema nodosum leprosum reactions indicates that altered TLR1 function, or at least a TLR1 N248S-linked trait, may affect the progression from infection to disease as well as the disease course and the risk of debilitating reactional episodes in this population.
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