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  • Title: Acute megakaryocytic leukemia (AMKL) with major myelofibrosis in an infant. Diagnosis by liver biopsy and response to treatment.
    Author: Garel D, Mielot F, Gaulard P, Quillard J, Dommergues JP, Tchernia G.
    Journal: Nouv Rev Fr Hematol (1978); 1991; 33(1):5-8. PubMed ID: 1945824.
    Abstract:
    An infant presented with enlarged liver and spleen and profound pancytopenia. Severe marrow fibrosis impeded the diagnosis which was achieved by liver biopsy: Fibrosis surrounded foci of blasts which were shown by immunologic markers to originate from the megakaryocytic lineage. Complete sustained remission was obtained by low-dose aracytine therapy. The child was disease-free at 40 months' follow up.
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