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  • Title: [Distribution of specific IgG subclasses in patients with pertussis and in healthy persons].
    Author: Zaĭtsev EM, Mazurova IK, Petrova MS, Krasnoproshina LI, Astakhova TI, Zakharova NS.
    Journal: Zh Mikrobiol Epidemiol Immunobiol; 2009; (2):57-61. PubMed ID: 19459479.
    Abstract:
    AIM: To assess level of IgG1, IgG2, IgG3, and IgG4 to complex of antigens of Bordetella pertussis in patients with whooping cough and healthy children and adults. MATERIALS AND METHODS: Levels of anti-pertussis IgG subclasses in sera of patients with pertussis and healthy children and adults were measured with solid phase immunoenzyme assay using peroxidase-conjugated monoclonal antibodies to human IgG1, IgG2, IgG3, and IgG4. RESULTS: In patients with pertussis, IgG1-IgG3-IgG2-IgG4 type of distribution of subclasses with predominance of IgG1 and IgG3 was revealed. In healthy children and adults the character type of subclasses distribution was IgG1-IgG2-IgG4 with absent or low level of IgG3. CONCLUSION: Detection of specific IgG3 mainly in patients with pertussis allows to consider them as a reliable serological sign of pertussis infection.
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