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  • Title: [The inhalation 1 concentration test for the assessment of bronchial reactivity].
    Author: Hoffarth HP, Reier W, Reichel G, Ulmer WT.
    Journal: Pneumologie; 1991 Aug; 45 Suppl 2():690-4. PubMed ID: 1946279.
    Abstract:
    An unspecific bronchial provocation challenge with a 1-concentration test is a reliable method to distinguish between normal and hyperreactive persons. The patient inhales a bronchoconstricting substance such as methacholine. A significant change of lung function, for example an increase of airway resistance, characterizes a hyperreactive bronchial system. The continuous registration of transcutaneous oxygen pressure is helpful concerning a strong reaction or a peripheral airway obstruction. An exaggerated increase of airway resistance after provocation test can be treated rapidly by inhalation of sympathicomimetics. No complications were registered. Comparative studies showed a good reproducibility of this method. Summarizing, the 1-concentration test is simple, easy to perform and suitable especially for investigations in occupational medicine or epidemiology.
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