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  • Title: [Various enzymes of isolated nuclear membranes and cell nuclei of the liver and hepatoma 27 of rats].
    Author: Koen IaM, Perevoshchikova KA, Zbarskii IB.
    Journal: Biokhimiia; 1976 Jul; 41(6):982-8. PubMed ID: 194629.
    Abstract:
    A comparative study of glucose-6-phosphatase, alcaline RNase, ATPase, inosine diphosphatase and 5'-nucleotidase activities in isolated rat liver and hepatoma-27 nuclei and nuclear envelopes was performed. The tumor nuclear membranes were shown to be free from G-6-Pase activity in contrast to the liver nuclear membranes. The nuclear RNase activity was strongly inhibited in the hepatoma and could be unmasked in the presence of 3-10(-4) M pCMB. Hepatoma nuclear and nuclear envelopes ATP-ase activity was found to be moderately decreased as compared to those of the normal tissue. The values of inosine diphosphatase activity in hepatoma were similar to those in liver. The role of the nuclear envelope in nuclear-cytoplasmic interactions as well as nuclear location of G-6-Pase are discussed.
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