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  • Title: [Micafungin for therapy of invasive candidiasis in solid organ transplant recipients].
    Author: Fortún-Abete J.
    Journal: Rev Iberoam Micol; 2009 Mar 31; 26(1):65-8. PubMed ID: 19463280.
    Abstract:
    BACKGROUND: Micafungin is an echinocandin approved for the prevention of Candida spp. infection in hematopoietic stem cell transplantation and therapy of oesophageal candidiasis, disseminated candidiasis and candidemia in adults, children and neonates. AIMS: To evaluate the role of micafungin for candidiasis therapy in solid organ transplant recipients. METHODS: A medical literature review according to micafungin role for candidiasis therapy in transplant patients is performed. RESULTS: Micafungin has shown fungicide activity against Candida species, including strains resistant or poorly susceptible to fluconazole. No dose adjustment is required when micafungin is administered in combination with other drugs used in transplant patients, excluding sirolimus, nifedipine and itraconazol. With these drugs, a minimal dose reduction is recommended. The results observed in transplant patients included in clinical trials are favourable and similar to results obtained in other kind of patients. CONCLUSIONS: The clinical results, its safety profile and the low grade of medical interactions permit micafungin to be considered for therapy in specific groups of transplant patients.
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